Authors : Seiya Matsui, Kazumi Sasai and Tadayoshi Takeuchi
Abstract: Fat cadherins are huge proteins that contain 34 cadherin repeats. Recent studies showed that human Fat2 was expressed at squamous cell carcinoma and mammal fat cadherins related to tumor. It is possible to speculate that Fat2 relate skin tumors. Canine skin tumor is one of the most common diseases and some skin tumors like melanoma are devastating. Therefore, many kinds of investigation about skin tumor are necessary for a certain and prompt diagnosis and prediction. We investigated the expression of Fat1 and Fat2 mRNA in canine skin biopsies by RT-PCR. Samples of skin tissue were obtained from five healthy dogs and skin tumors of nine dogs from private veterinary hospital (Kitasuma Animal Hospital and Matsuoka Animal Hospital). Fat2 mRNA was not expressed in normal canine skin. However, we found that canine Fat2 mRNA was expressed in six of nine (67%) canine skin tumors. On the other hand, canine Fat1 mRNA was not detected in canine normal skin and skin tumors. These results indicate that Fat2 might relate to skin tumors in dogs. The further study of Fat2 in dog might be important for clarifying the mechanism of skin tumors and developing the treatment.
Seiya Matsui, Kazumi Sasai and Tadayoshi Takeuchi, 2012. Expression of Fat2 mRNA in Canine Skin Tumors. Journal of Animal and Veterinary Advances, 11: 2289-2292.