Authors : Bin Tong, Youji Muramatsu, Takuji Yamamoto, Hideki Tanomura, Takeshi Ohta, Hiroyuki Kose, Toshie Sugiyama and Takahisa Yamada
Abstract: Researchers have previously showed that the triadin (TRDN) gene involved in muscle contraction possesses expression differences in musculus longissimus muscle between low-marbled Holstein and high-marbled Japanese Black steer groups. In the present study, researchers found that a marker (BMS817) close to the TRDN was polymorphic between low-marbled Holstein and high-marbled Japanese Black steer groups and exhibited significantly different allelic distribution between Japanese Black sires with extremely high predicted breeding value for marbling and with extremely low one. Further, researchers detected Single Nucleotide Polymorphism (SNP) in the TRDN gene between low-marbled Holstein and high-marbled Japanese Black steer groups. The allelic distribution of the SNP referred to as g.3834941C>T in the TRDN was indistinguishable between Japanese Black sires with extremely high predicted breeding value for marbling and with extremely low one. The findings suggest that an unidentified true causal mutation which is in linkage disequilibrium with the BMS817 marker but not the g.3834941C>T SNP may be related to changes in TRDN gene expression and/or marbling. The BMS817 marker may be useful for effective marker-assisted selection to increase the levels of marbling.
Bin Tong, Youji Muramatsu, Takuji Yamamoto, Hideki Tanomura, Takeshi Ohta, Hiroyuki Kose, Toshie Sugiyama and Takahisa Yamada, 2012. Useful Marker Around TRDN Gene Showing Marbling-Associated Expression Changes. Journal of Animal and Veterinary Advances, 11: 2792-2795.