Abstract: Clinical trials have documented that amantadine hydrochloride is effective drug for the prophylaxis and treatment of influenza A virus infection. Newsday use of amantadine for treatment of influenza has been increased. The aim of present study was to determine the effect of Amantadine on serumic levels of ALT, AST and ALP in native poultry. About 10 adult hens weighing between 2 and 2.5 kg were used for the study. In first steps one blood sample were taken. In secondary steps amantadine (orally) with dose of 25 mg kg-1 for 4 consecutive weeks were administrated. Blood samples in days of 1, 3, 7, 14, 21 and 28 after administration from every hen were taken and after centrifugation serums for seral titration of ALT, AST and ALP by standards kits were used. In fact study according to results of present study a significance in serumic levels of AST in 21, 28 and ALP in 3 , 7, 14, 21, 28 after orally amantadine administration were observed.
Khayatnouri Mirhadi, Yagoobnegad Alireza and Safarmashaei Saeid, 2012. Effect of Amantadine on Serumic Levels of ALT, AST and ALP in Native Poultry. Journal of Animal and Veterinary Advances, 11: 64-66.