Journal of Animal and Veterinary Advances

Year: 2013
Volume: 12
Issue: 15
Page No. 1266 - 1270

Effect of Alanine Supplementation on Vaccine Immunized Mice

Authors : Pan Zhang and Jianlong Wang

Abstract: This study was conducted to test the immunostimulatory effect of graded dose of alanine supplementation on inactivated vaccine immunized mice. Animals were randomly divided into five groups: mice were immunized with inactivated vaccines, mice were treated with dietary 0.5% alanine supplementation and immunized with inactivated vaccines, mice were treated with dietary 1.0% alanine supplementation and immunized with inactivated vaccines, mice were treated with dietary 2.0% alanine supplementation and immunized with inactivated vaccines and all the mice immunized with PBS. Results found that alanine supplementation has little significant effect on serum antibody production, serum interleukin-1 beta and 8 levels and survival rate of mice after challenge. However, higher dose of alanine supplementation increased serum GSH-PX activity compared to the lower dose of alanine supplementation. Collectively, dietary alanine supplementation has little effect on the immune parameters in vaccine immunized mice indicating alanine can be used as isonitrogenous control to study the immune regulatory function of other amino acids.

How to cite this article:

Pan Zhang and Jianlong Wang, 2013. Effect of Alanine Supplementation on Vaccine Immunized Mice. Journal of Animal and Veterinary Advances, 12: 1266-1270.

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