Abstract: The present study was carried out to investigate anti-fatigue activity of Crude saponins from Panax quinquefolium (CPQS) in mice. The animals were randomly divided into four groups: control (distilled water); 50 mg kg-1 CPQS; 100 mg kg-1 CPQS and 200 mg kg-1 CPQS. Distilled water or CPQS were orally administered for consecutive 28 days. The 28 days later, forced swimming test was performed and then fatigue-related biochemical parameters including blood lactic acid, serum urea nitrogen, liver glycogen and muscle glycogen were detected. The results showed that CPQS could prolong the swimming to exhaustion time of mice as well as increasing the liver and muscle glycogen contents but decrease the blood lactic acid and serum urea nitrogen levels. Therefore, the present study demonstrated that CPQS possessed anti-fatigue activity.
Xing Jin-Ming, Yuan Wen-Xue , Zhang Zhi-Cheng and Chen Shuai , 2013. Anti-Fatigue Activity of Crude Saponins from Panax quinquefolium. Journal of Animal and Veterinary Advances, 12: 584-588.