Authors : Dongying Yang
Abstract: As a cytokinin growth factor kinetin (N6-furfuryladenine) with several biological effects observed for human cells and fruit flies. It was named kinetin because of its ability to induce cell division. The mechanism of kinetin synthesis in DNA is thought to be via the production of furfural, an oxidative damage product of DNA deoxyribose and it is quenched by the adenine base converting it into N6-furfuryladenine. Since 1994, kinetin has been thoroughly tested for its powerful antiaging effects in human skin cells and other systems. At present, kinetin is one of the most widely used components in numerous skin care cosmetics and cosmeceuticals. Kinetin which was isolated 50 years ago for the first time as a plant hormone as well as other cytokinins isopentenyladenine, zeatin and benzylaminopurine induce callus (clusters of dedifferentiated plant cells) to redifferentiate into adventitious buds. Because of some similarities in the biological phenotypes of cancer and callus cells, cytokinins and especially kinetin, affect the differentiation of human cells through a common signal transduction system. Therefore, cytokinins found their way to use in molecular medicine.
Dongying Yang , 2013. Biological Activities of Kinetin on Animals. Journal of Animal and Veterinary Advances, 12: 671-675.