Authors : Yihan Dong, Peng Liu, Xiaoli Wei and Kaiming Su
Abstract: To investigate the epidemiological characteristics of the Esptein-Barr Virus (EBV) in Otitis Media with Effusion (OME) and its role in the pathogenesis of OME. The plasma samples of 65 patients with OME and 70 healthy people were tested for EBV by real-time quantitative PCR technique. Genomes of EBV positive rate in OME patients are 38.5% (25/65) while only 2.8% (2/70) in control group (p = 0.0001). EBV infection rate in patients with B type tympanogram is higher than that of C type (p = 0.006). No difference of EBV-DNA infection rate was found between the male and female (p = 0.5) or patients with unilateral and bilateral OME (p = 0.076). According to the treatment effect grouping, the EBV infection rate is 17.5% in patients with the subjective symptoms disappeared in three months after treatment, significant lower than that not disappeared or worsen in 3 months (72%, p = 0.001). EBV infection may contribute as a cause of OME and seems to affect the treatment effect. More extensive study are required to elucidate the role of the EBV and the relationship of OME.
Yihan Dong, Peng Liu, Xiaoli Wei and Kaiming Su, 2013. Determination of Esptein-Barr Virus in the Plasma of Adult Patients with Otitis Media with Effusion. Journal of Animal and Veterinary Advances, 12: 81-84.