Authors : Takehito Suzuki, Natsumi Kitada, Hirokazu Sakamoto, Hiroshi Kubo, Tatsuya Takizawa and Katsuji Uetake
Abstract: Elderly beagles were subjected to periods of constant exercise loads on a treadmill following administration of a reduced form coenzyme Q10 (ubiquinol) for 30 days. The anti-fatigue effect of ubiquinol on the capacity for exercise was evaluated. When ATP consumption is elevated during exercise, it is thought that ubiquinol contributes to supplying energy by promoting ATP biosynthesis. Here, we demonstrate that administration of ubiquinol suppressed serum IL-6-induced catabolism and TGF-β-associated fatigue perception. Furthermore, induction of sirt1 gene expression and the associated activation gluconeogenesis was not induced. Lastly, PPAR-α and PPAR-γ which regulate mitochondrial composition and the acceleration of energy production by mitochondrial hyperfunction were not influenced by ubiquinol administration.
Takehito Suzuki, Natsumi Kitada, Hirokazu Sakamoto, Hiroshi Kubo, Tatsuya Takizawa and Katsuji Uetake, 2014. Anti-Fatigue Effects of Oral Supplementation with Reduced Coenzyme Q10 in Adult and Elderly Dogs. Journal of Animal and Veterinary Advances, 13: 1066-1071.