Authors : Lu Lu, Xiu Huang, Long Zhang, Dan Lan, Di-yan Li, Yi-Ping Liu and Yao-Dong Hu
Abstract: Antimicrobial Peptides (AMPs) are principal defense system for most organisms. Multiple AMPs have been characterized as widespread conserved component and showing a wide spectrum of effectiveness to the various microorganisms. Despite of the antibacterial activity, AMPs have also been found can serving as other immune effects including modulation of inflammatory responses, promotion of wound healing and chemotactic activity. AMP drugs have been actively developed and lightly applied in animal production. In this review, we will brief the activities and functional mechanisms of AMPs as well as a warning of the potential resistance to AMPs used directly. Moreover, we will focus on a potential application strategy, by regulating the expression of AMPs which may delay or avoid the resistance to AMPs. Finally, the status and obstacles of AMPs used in domestic animals will be described.
Lu Lu, Xiu Huang, Long Zhang, Dan Lan, Di-yan Li, Yi-Ping Liu and Yao-Dong Hu, 2014. Antimicrobial Peptides Characteristics and their Application in Domestic Animals. Journal of Animal and Veterinary Advances, 13: 1185-1193.