Authors : Fatima Laiche, Noureddin Djeblia, Ahed Alkhatib and Murtala Muhammad
Abstract: Parkinson disease is a common neurodegenerative disease. Deficiency of dopamine is thought to be responsible for development of Parkinson disease. Exercise training has been associated with improvements in patients with Parkinson disease. The objective of the present study is to explore the effect of exercise training on the expression of HSP70 in brains of mice with induced Parkinson disease. Forty albino mice were selected and assigned into four groups: Sedentary Control (SC, N = 10), Exercised Control (EC, N = 10), Parkinson Disease (PD, N = 10) and Exercised Parkinson Disease (EPD, N = 10). MPTP protocol was used to induce Parkinson disease by injections of 10 doses of MPTP (25 mg kg-1) and probenecid (250 mg kg-1) over 5 weeks. After the protocols treadmill exercise training had been finished, samples from the brain tissues were assessed by immunohistochemistry to examine the expression of HSP70 in the four groups of animals. The results of the present study showed that the expression of HSP70 was reduced in the brain of mice with Parkinson disease significantly (p≤0.05) compared with control groups. The results also showed that exercise training increased the expression of HSP70 in EC significantly (p≤0.05) compared with control group and insignificantly (p>0.05) in EPD compared with PD. Although, the increased expression of HSP70 in exercised Parkinson disease was not significant, it has a potential role in improved the status of mice with Parkinson disease and it may have a potential therapeutic role.
Fatima Laiche, Noureddin Djeblia, Ahed Alkhatib and Murtala Muhammad, 2014. Exercise Training Upregulates the Expression of HSP70 in Brain of Mice with Induced Parkinson Disease. Journal of Animal and Veterinary Advances, 13: 302-305.