Abstract: Baron is herbicide includes (48% glyphosate) widely used in Egypt. The present study assess cytotoxic and genotoxic effect of Baron on rats liver. Two groups of rats were treated orally with 1/10 LD50 (275.49 mg kg-1) and 1/40 LD50 (68.86 mg kg-1) glyphosate for 28 days compared with control group. Serum and liver tissues were taken at 14 and 28 days of treatment. An inhibition in Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) activites were recorded at both treatment periods and reduction in Total serum Protein (TP) and Albumin (ALB). However, non-significant changes in serum Acetylcholinesterase (AChE). Elevation in oxidative stress biomarker Malondyaldehyde (MDA) and decline in detoxification biomarkers total reduced Glutathione (GSH), Glutathione S-Transferase (GST) and Superoxide Dismutase (SOD) in liver tissue led to increase in percentage of DNA damage. Destruction in liver tissue architecture was observed. Although, Baron was classified in the safe category pesticides repeated exposure to small doses has great danger effect.
Manal E.A. Elhalwagy, Nadia Amin Abdulmagid, Hanan S. Alnahdi and Enas N. Danial, 2014. Hepatoxicity Induced by Glyphosate-Based Herbicide Baron in Albino Rats. Journal of Animal and Veterinary Advances, 13: 322-329.