Authors : Yue Yin, Xi Lan, Kai Tian, Tian-Jie Li, Qing Zhu, Yi-Ping Liu, Xiao-Ling Zhao, Hua-Dong Yin, Yao-Dong Hu and Yan Wang
Abstract: Interferon-β (IFN-β) and immunoglobulin M (IgM), immunoglobulin G (IgG) are essential in anti-retrovirus progress. ALV-J is a kind of ubiquitous retrovirus in chicken. To investigate whether natural Avian Leukosis Virus strain J (ALV-J) infection has effect on the concentrations of serum IFN-β, IgM and IgG, two important time points after hatching, 3 and 18 weeks age which represent the early and late stages of ALV-J infection, respectively were decided to study. The results reveal that the serum IFN-β, IgM and IgG increase at the early stage of ALV-J infection while decrease at the late stage compared with the control chickens which indicate that ALV-J infection boosts the immune response and up-regulates IFN-β and antibody while long-term infection suppresses immune function and down-regulates IFN-β and antibody.
Yue Yin, Xi Lan, Kai Tian, Tian-Jie Li, Qing Zhu, Yi-Ping Liu, Xiao-Ling Zhao, Hua-Dong Yin, Yao-Dong Hu and Yan Wang, 2014. The Differences of Serum IFN-β and Antibodies Concentrations in Chickens at Early and Late ALV-J Infection Stage. Journal of Animal and Veterinary Advances, 13: 930-936.