Abstract: The present work examines the potential Teucrium polium L. extracts as a source of natural antioxidant and antimicrobial compounds. Total antioxidant activity, DPPH radical scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, metal chelating activities, reducing power, antimicrobial activity and total contents of phenolic compounds of dried T. polium samples, which extracted with chloroform and acetone were studied. The total antioxidant and the others antioxidant activities of T. polium are increased with increasing amount of sample (50-250 ?g). However, the chloroform extract of T. polium exhibited stronger antioxidant activity than the acetone extract. In the both extracts, the highest total antioxidant activity, DPPH? radical scavenging activity, metal chelating activity and total phenolic compounds were found in chloroform extract of T. Polium. In addition, the both extracts showed strong antioxidant activity comparable with -tocopherol. Antimicrobial activity of the both T. polium extracts were examined by means of disc-diffusion methods with eleven microbial species (Bacillus megaterium, Proteus vulgaris, Listeria monocytogenes, Bacillus cereus, Staphylococcus aureus, Bacillus brevis, Klebsiella pneumoniae, Micrococcus luteus, Pseudomonas aeruginosa, Escherichia coli and Mycobacterium smegmatis and four fungal species (Penicillum frequentans, Fusarium equiseti, Aspergillus candidus, and Byssochlamys fulves). The both extracts were effective in inhibiting the growth of the organisms except for Escherichia coli. Antifungal activity of each of above extracts is lower than antimicrobial activity relatively.