Abstract: A total of 7 bacteria, which displayed antagonist activity against indigenous fungi in vitro, were isolated from grated cassava, starch and flour samples. Cultures were pooled and tested for anti-fungi activity, inhibited growth of the fungal pathogens and the protective effects of the various bacterial isolates. The effects of the treatment on the haematological factors were studied on albino rats. No negative haematological (packed cell volume, haemoglobin counts, white blood cell counts and differential white cell counts) effect was observed. However, treatments with Bacillus sp., Pseudomonas fluorescens and Escherichia coli resulted in low WBC counts when compared with the control. The RBC and WBC morphology for all appeared normal. The improvement in blood composition that followed treatment of the animals with the bacterial isolates indicated an immunological security.