Abstract: This study investigated the determinants of workers’ morale and satisfaction with research conditions in industrial organizations in South-Western Nigeria. This was for the aim of ascertaining the causal-factors of satisfactory behaviour and morale among industrial workers in Nigeria. The descriptive survey method was adopted for the study. A total of 327 respondents, from public and private organizations were selected for the study using stratified proportionate sampling technique. For data collection, the researcher utilizes 2 set of questionnaires titled Determinants of Workers’ Morale Scale (DWMS) which was developed by Clovin and the Causal-Factors of Job Satisfaction scale (CFJS), which was developed by Bakare. The findings of the study revealed that leadership behaviour, perception of research itself, autonomy on the job, interpersonal relations at workplace, organizational support system, training and development, working environment and provision for retirement benefit were perceived as factors that determine workers’ morale and satisfaction. It was also found that no significant difference exist between the perceptions of male and female respondents’ on factors influencing morale and satisfaction with work conditions. Furthermore, there was no significant difference found between the perceptions of male and female respondents’ on factors influencing morale and satisfaction with work conditions. Moreover, no significant difference was found between the perceptions of respondents with high and low education on factors influencing morale and satisfaction with work conditions. The findings further revealed that there is no significant difference between the perceptions of experienced and less experienced respondents on factors influencing morale and satisfaction with work conditions. Based on the findings of the study; it is recommended that the organizational support programmes should be provided to embrace training and development, substantive welfare package and provision of adequate pension schemes for workers. This will definitely facilitate improved workers’ morale and satisfaction with work conditions.