Abstract: Oxidative stress plays a role in cardiovascular dysfunction. This is of interest in diabetes, a clinical conditions characterized by oxidative stress and increased previous of cardiovascular disease. Itís the leading causes of death in people with diabetes type II (non insulin dependent)or NIDDM. This disease is very common metabolic disorder affection of hyperglycaemia and insulin resistance suppose by important roles of dyslipideamia, (cause of peroxydation, so increase free radicals and damage. So the optimal diet for persons with diabetes has long been a subject of controversy. Dietary therapy was the only treatment available in the era before insulin therapy. The goal of nutrition and medical therapy in diabetes is to prevent complication by maintenance of glycaemia control and other parameters like lipoproteins and cholesterol. Nutritionally beneficial compounds naturally present in vegetables seeds are an original source of fats and fats soluble vitamins, phytosterols ectÖ both important in human diet and to prevent complications, so in this idea we use Citrullus colocynthis as source of oils (this plant is known by numerous therapeutically properties, is used by the diabetic population NIDDM) in isocaloris diet in induced streptozotocin diabetic male Wistar rats. In this study, we evaluate in the first, the effect of this oil compared with sun flower on glucidic, lipidic metabolim and on hepatic activity, so we measured levels of glucose, insulin, Cholesterol, Triglycerides, NEFA, C-LDL, C-HDL in plasma, glutathione and Malondialdehyde (MDA) in liver homogenates of the rats fed a diet with the different oils. Our results show clear correction of atherogene parameters (CT,TG,NEFA and C-LDL) in diabetics rats versus non diabetics rats,an increase of the glutathione level and decrease of MDA levels in diabetic rats fed with diet 2. Colocynthis oil diet increased the diminsched vitamin A levels in diabetic rats and vitamin C concentrations. Also, this improved the decreased erythrocyte superoxyde dimutase and glutathione peroxidase activities in diabetic.
N. Sebbagh , D. Chabane Sari , S.A. Taleb , M. Benyoucef , M. Lahouel , A. Ktorza and C. Magnan , 2007. Effects of Dietary Colocynthis and Sunflower Fatty Acids Containing Oils on Lipid Metabolism and on Antioxidant Parameters in Streptozotocin-Induced Diabetic Rats . Research Journal of Applied Sciences, 2: 832-838.