Abstract: The ECG finds its importance in the detection of cardiac abnormalities. ECG signal processing in an embedded platform is a challenge which has to deal with several issues. Noise reduction in ECG signal is an important task of biomedical science. ECG signals are very low frequency signals of about 0.5-100 Hz. There are various artifacts which get added in these signals and change the original signal, therefore there is a need of removal of these artifacts from the original signal. The noises that commonly disturb the basic electrocardiogram are power line interference, electrode contact noise, motion artifacts, Electromyography (EMG) noise and instrumentation noise. These noises can be classified according to their frequency content. In this study, these we have used wavelet transform based approach for removing these noise. In this study, the Discrete Wavelet Transform (DWT) at level 8 was applied to the ECG signals and decomposition of the ECG signals was performed. After removal of noise component using thresholding technique, decomposed signal is again constructed using Inverse Discrete Wavelet Transform (IDWT). Here for de-noising the ECG signal, bi-orthogonal wavelet transform is used and the most efficient idea for noise removal process is concluded with this wavelet transform. The simulation has been done in MATLAB environment. The experiments are carried out on MIT-BIH database. Performance analysis was performed by evaluating Mean Square Error (MSE), Signal to Noise Ratio (SNR), Peak Signal to Noise Ratio (PSNR) and visual inspection over the de-noised signal from each algorithm.