Authors : Seyed Jafar Navabi, Amir Jalali, Mansour Rezaei and Hossein Amiri
Abstract: Fatty liver disease in non-alcoholic patients is among diseases causing changes in the body�s metabolism, especially lipid metabolism. Therefore, with changes in the metabolism of fatty liver, uric acid can be expected to rise in the body. This study was conducted to determine the relationship between levels of uric acid and the severity of non-alcoholic fatty liver disease in patients referred to Kermanshah University of Medical Sciences affiliated clinics in 2016. This study was a cross-sectional and analytical research. The subjects included all patients referred to clinics within the city of Kermanshah that their non-alcoholic fatty liver disease diagnosis and grade had been confirmed by ultrasound. By available sampling method, 215 subjects were selected. In a single laboratory, using the same assay kit their uric acid and other blood biochemical tests were evaluated and the resulted data were analyzed using SPSS Version 18. The results showed that the mean blood uric acid level of samples was equal to 6.44±1.55 mg dL–1. The mean values in men and women were as 6.95 and 5.88 mg dL–1, respectively that the difference was statistically significant (p<0.05). The mean value of blood uric acid of the samples would rise according to the non-alcoholic fatty liver grade. The ANOVA and Spearman ranking test showed no significant difference and relationship. The study results showed that high levels of uric acid in patients with fatty liver disease can be strong evidence on the severity of patients� fatty liver. Therefore, to find out the situation and severity of fatty liver of patients they should be examined and followed up with more accurate methods like ultrasound, biopsy or advanced imaging methods.
Seyed Jafar Navabi, Amir Jalali, Mansour Rezaei and Hossein Amiri, 2016. Study of the Relationship Between Uric Acid and Severity of Non-alcoholic Fatty Liver among Patients Referred in Kermanshah University of Medical Sciences’ Clinics. Research Journal of Applied Sciences, 11: 406-409.