Abstract: Nitrogen dioxide (NO2) is one of the air pollutants whose concentration is increasing due to the increased number of vehicles as a mode of transportation. Exposure to NO2 causes physical symptoms of respiratory disorders and lung function and Alpha 1 Antitrypsin (AAT) plays a role in the protection of inflammation due to exposure to NO2 through inactivation by nitrogen. This study aims to reveal the relationship of NO2 exposure, AAT and lung function of the traffic police in Jakarta. It is a cross sectional study with 112 traffic police as research subjects divided into two groups: the police working on the highway and working in the office. NO2 measurement of the environment is carried out at the location where the subjects work and examination is done toward lung physiology, AAT levels, body weight, body fat percentage, height and waist circumference as a factor in determining lung function. NO2 levels are 18.72 ppb on highways (high exposure areas) and 4.14 ppb in the office (low exposure area), respectively. There are 49% of the traffic police working on the highway (high exposure to NO2 ) and 51% of police officers working in the office (low exposure to NO2 ). Mean of pulmonary physiology, represented by percentage of FVC (Forced Vital Capacity), on the entire subject is 89.49 and mean of FEV1 (Forced Expiratory Volume in 1 sec) is 95.39. The mean of FEV1 compared to FVC is 88.4 and there is no significant difference between police officers working in the highway and working in the office. AAT levels in both subjects show normal values compared to normal levels of AAT standard of 141.07 mg/dL. Finally, the prediction model obtained in the end which is the prediction of FVC percentage and FEV1 percentage for both the dependent variable has a normal distribution. In conclusion, the value of lung function for police officers working on the roads is lower than the value of lung function of those working in the office. Factors that affect lung function in this study are NO2 levels, AAT, fat, age (35 years old), visceral fat and waist circumference.
Satria Pratama, Bambang Wispriyono, Haryoto Kusnoputranto and Faisal Yunus, 2018. The Role of Alpha-1 Antitrypsin Enzyme on Pulmonary Dysfunction Due to Exposure to NO2. Research Journal of Applied Sciences, 13: 229-234.