Authors : M.I. Hassan, H.A. Mazlee and N. Sultana
Abstract: Over the past few decades, electrospun nanofiber has been introduced as one of the suitable drug carriers for drug delivery application. A special property exhibited by the nanofiber is that it has an extremely high surface area to volume ratio which makes it suitable to be applied in this application. In fact, there has been a lot of considerable interest in developing electrospun nanofiber using an electrospinning technique. In this study, a synthetic polymer, Polycaprolactone (PCL) was blended with a natural polymer, chitosan to fabricate electrospun nanofibers for drug delivery application. The ratio of the polymer blending composition for PCL/Chitosan was varied. The solution viscosity was measured by a viscometer. The morphology of the nanofibers was observed using a Scanning Electron Microscopy (SEM) and wettability was measured using a water contact angle measurement. At suitable polymer blend composition and viscosity, it was possible to fabricate electrospun nanofibers with diameter of 85-120 nm. It was also observed that the wettability of the nanofibers was 63.03±6.02°.
M.I. Hassan, H.A. Mazlee and N. Sultana, 2018. Effects of Solution Viscosity on the Fabrication of Polycaprolactone (PCL)/Chitosan Nanofibers. Research Journal of Applied Sciences, 13: 632-635.