Abstract: Although, deaths due to asthma usually happen out of the hospital, but high risk children may be identified upon their previous medical history before admission toPediatric Intensive Care Unit (PICU). Patients who do not respond considerably to primary treatments in emergency department must be transferred to PICU for close observation, monitoring and further treatment. According to burden of asthma and its fatality if not be classified or treated properly, the early recognition of high-risk asthmatic children who must be admitted to PICU and to avoid unnecessary admissions, play a significant role in management of asthma, therefore we planned this study to identify predictive factors of PICU admission for asthmatic children. This comparative (analytical) and cross-sectional study on 70 asthmatic children (40 patients admitted to ward and 30 patients to PICU) carried out to determine epidemiologic and clinical factors, laboratory and radiologic findings and treatments in 2 groups of patients, who admitted to PICU versus respiratory ward. Statistical tests including t-test and Chi-square were used to analyze and compare results between these groups. This study revealed some statistically significant difference in presenting clinical signs such as Cyanosis (p = 0.0001), Tachypnea (p = 0.04) and Tachycardia (p = 0.01) between 2 groups of patients, who admitted to PICU versus respiratory ward. Besides, there were some meaningful differences in their laboratory findings, including lower PaO₂ (p = 0.03) and higher PaCO₂ (p = 0.02) in patients admitted to PICU than who admitted to ward. Previous positive history of PICU admission and/or inappropriate medical treatment was more common in PICU admitted patients than ward admitted group. We concluded that cyanosis, rapid respiratory and pulse rates, low PaO₂, high PaCO₂, previous positive history of PICU admission and inappropriate medical treatment, all prepare an asthmatic patient to need PICU readmission.