Abstract: Our goal was to assess the association between hostility, current psychological morbidity and quality of life in Irritable Bowel Syndrome (IBS). A purposive sample of 57 patients diagnosed with Irritable Bowel Syndrome and a group of matched controls constituted the sample of the study. Data was collected using the Buss-Durkee Hostility Inventory (BDHI), State-Trait Anxiety Inventory (STAI) and the Quality of Life Questionnaire (WHOQOL-BREF). Information was also gathered on patient demographics, disease history, symptom rate of recurrence, health care use, medication use and the influence of symptoms on productivity and daily activities. All data were subject to multivariate analyses of variance to reveal group differences. Regression analysis was run to determine the factors that impact quality of life. Findings demonstrate that, overall, patients with IBS experience poorer quality of life compared with their normal counterparts. Furthermore, IBS patients reported greater anxiety, indirect aggression, irritability and suspicion than normals. Regression analysis revealed trait anxiety and attribution of illness to psychological causes as predictors of quality of life. Findings illustrate that to improve functional ability and quality of life in IBS patients, gastroenterologists should consult with psychiatric services to provide assessment irrespective of IBS symptom severity.