Authors : Bilan Nemat , M. Shoaran and Asvadi Atabak
Abstract: Asthma is a chronic airway disorder and prevalence of asthma symptoms in children is about 1-30% and is increasing in many countries. Inhaled Corticosteroids (ICS) are one of the basic therapeutic agents for asthma and their daily frequency is one of the most important factors in the patient adherence to therapy. This study was designed to compare the effect of different frequencies of Fluticasone Propionate on the treatment of mild persistent asthma. This study is a randomized clinical trial on 100 patients with mild persistent asthma at the age of 2-14 years-old receiving Fluticasone Propionate 1 puff twice daily for first 3 months and then 2 puffs once daily for next 3 months are compared to 150 asthmatic patients with the same age range and severity of disease but receiving 1 puff twice daily for 6 months. There was no significant meaningful difference in therapeutic effects of Fluticasone Propionate between two studied groups but adherence to therapy was better in once-daily administered group. Considering the lack of significant difference between two groups and increased parental adherence in first group, the lower frequencies of spray administration after a partial improvement is suggested.
Bilan Nemat , M. Shoaran and Asvadi Atabak , 2008. Efficacy Evaluation of Different Treatment Regimens with Fluticasone Propionate in Mild Persistent Asthma. Research Journal of Biological Sciences, 3: 1373-1375.