Authors : Maryam Ghasemi , Farshad Naghshvar , Said Abedian Kenari , Asadollah Mohseni Kiasary , Laleh Vahedi Larijani and Ebrahim Nasiri
Abstract: Coronary heart disease remains a leading cause of morbidity and mortality and several risk factors have been shown that play role in its pathogenesis. Several studies suggested that there is an between Chlamydia pneumoniae and coronary artery disease as a curable etiology. The aim of this study was to evaluate the relationship between Chlamydia pneumoniae-specific antibodies and angiographically demonstrated coronary artery disease in Iranian patients. This study performed on 180 subjects, admitted for coronary artery angiography in Mazandaran Heart Center, Sari, Iran, in 2006. Patients divided in two case and control groups according to evidence of atherosclerosis in angiography. Both groups were matched from the viewpoints of age, gender, cigarette smoking, diabetes mellitus, dyslipidemia and hypertension. The presence of IgG and IgA antibodies to Chlamydia pneumoniae in patient`s serum assessed with enzyme-linked immunosorbentassay. Out of 180 patients, 90 (27 men and 60 women) with mean age of 55.32±10 years in case group and 90 patients (36 men and 64 women) with mean age 54.32±10 years in control group examined. According to angiography in case group 86 cases (95.5%) had stenosis in Right Coronary artery, 63 cases (70%) in Left circumflex artery and 67 (74.4 %) in Left Anterior descending artery. In the case group, Chlamydia antibody was detected in 46 (51.1%) subjects whereas in control group in 34 (37.8%). The difference between 2 groups was significant (p = 0.04). Our study showed that Chlamydia pneumoniae-specific antibodies were associated with ischemic heart disease, which indicated Chlamydia pneumoniae may be has a role in pathogenesis of atherosclerosis.
Maryam Ghasemi , Farshad Naghshvar , Said Abedian Kenari , Asadollah Mohseni Kiasary , Laleh Vahedi Larijani and Ebrahim Nasiri , 2008. Association of Chlamydia Pneumoniae-Specific Antibody and Angiographically Demonstrated Coronary Artery Atherosclerosis in a Sample of Iranian Patient. Research Journal of Biological Sciences, 3: 171-175.