Authors : S. Gholamzadeh , S. Zare and M. Ilkhanipoor
Abstract: Echium amoenum belongs to the Boraginaceae family and is a biennial and perennial herb indigenous to the narrow zone of northern part of Iran and Caucasus. The flowers and leaves of this plant are used medicinally as ant febrile, anti-depressive, for the treatment of stress, laxative and anxiolytic. In this study we prepared an aqueous extract from dried petals of this botanical in 125 mg kg 1 concentration (effected dose on anxiety on basis of other researches) and tested the effect of extract on motor coordination in Rat as compared with diazepam 1 mg kg 1 as sedative and synthetic drug. Rotarod apparatus used in this study. The experiment did during 15 and 30 days. Statistical analysis of the latency to fall from the rotarod revealed that intraperitonealy administration of E. amoenum in 125 mg kg 1 and diazepam 1 mg kg 1 produced motor in coordination in 15 days but motor coordination in 30 days compared to control group.
S. Gholamzadeh , S. Zare and M. Ilkhanipoor , 2008. Effect of Echium amoenum (Gol-gav-zaban) on Motor Coordination in Rat During Two Treatment Courses . Research Journal of Biological Sciences, 3: 179-180.