Authors : A. Abedi , S. Khamneh , M. Mohammadi Naghadeh , H. Ibrahimi and J. Samadikhah
Abstract: Reports are available which suggest that depression of carotid baroreflex in Myocardial Infarction (MI) patients can occur. These patients are more subject to sudden death. The aim of the work presented here was to investigate carotid Baroreflex Sensitivity (BRS) in male patients after MI. Thus, in this study, we examined relation between decrease in BRS and duration of cardiac cycle in male MI patients. The study was performed on 15 infarcted male patients in the range of 40-70 years with the first cardiac attack and the same number of age matched healthy persons without any cardiac or pulmonary disease. the study was performed in both supine and seated positions. In order to estimate BRS, Neck Suction Devices (Eckberg Model) was used and electrocardiography (lead 2) was recorded continuously. Intensity of stimulation and duration of stimulation were 30 mm Hg and 30 sec, respectively. Duration of basic cardiac cycle in normal group in supine and seated positions was 0.8616+0.13 seconds and 0.8619+0.141 seconds respectively that increased to 0.9529+0.153 seconds and 0.9436+0.141 seconds after stimulation (p< 0.001). duration of basic cardiac cycle in patients group in supine and seated position was 0.0717+0.127 and 0.8215+0.11 sec, respectively that increased to 0.9124+0.153 and 0.8767+0.15 sec after stimulation (p< 0.05). When duration of basic cardiac cycle in supine and seated positions in patients was compared to healthy group, a different of 0.0511+0.011 (p< 0.001) in supine and 0.032+0.011 (p< 0.001) in seated position was observed. BRS significantly increased with age (R = 0.736: p< 0.001 for control and R = 0.66: p< 0.05 for patient group) in both groups and the differences were statistically significant. Adaptation in patients group was less compared to control group (R = 0.9, p< 0.001 for control group and r=0.673, p< 0.01 for patient group). This clinical study suggest that analysis of BRS in patients after MI can be important for prognosis and identifying MI patients at righ risk for sudden death merits careful examinations.
A. Abedi , S. Khamneh , M. Mohammadi Naghadeh , H. Ibrahimi and J. Samadikhah , 2008. Assessment of Carotid Baroreflex in Male Patients Suffering from Myocardial Infarction (MI) . Research Journal of Biological Sciences, 3: 269-274.