Authors : Silvia Tortorici , Francesco Burruano , Luigi Caradonna , Maria Lidia Buzzanca and Paolo Difalco
Abstract: Bisphosphonates are bone-turnover modulating drugs used to treat various diseases such as certain cancers, bone metastasis, bone- and calcium-related disorders, Paget`s disease, osteoporosis and osteopenia. Recently, several preliminary reports have reported the insurgence of osteonecrosis of the mandible and/or maxilla, associated with intravenously administered bisphosphonates. This case series describes the effects of bisphosphonates used in the treatment of certain cancers on oral bone tissues.
Silvia Tortorici , Francesco Burruano , Luigi Caradonna , Maria Lidia Buzzanca and Paolo Difalco , 2008. Maxillary Bone Necrosis Following the Use of Bisphosphonates in Patients with Cancer: Management and Case Series. Research Journal of Biological Sciences, 3: 925-929.