Authors : Lipari Luana, Gerbino Aldo, Farina Elvira, M. Buscemi and Lipari Alessio
Abstract: The sulpiride plays an effects on the hypothalamic hypophyseal axis. In this study, we study the effect of sulpiride on the hypothalamic supraoptic and paraventricular nuclei by measurement of the neuronal nuclear volume that is an index of their activity. The results show that many neurons present the nuclear volume similarly to controls but in one rat , M2, the percentage of neurons with lower nuclear volume than the controls indicating a little activity. The comparison between the histogram lines of supraoptic nucleus and paraventricular nuclei shows that in two cases the nuclear volume of the neurons of supraoptic is even more high than the paraventricular, while in a single case with the steady dioestrus, the percentage of neurons with high volume is less high in supraoptic nucleus than paraventricular nucleus indicating that the neurons of the supraoptic nucleus play a decrease activity than the neurons of the paraventricular nucleus in response to the sulpiride treatment. In conclusion, in women before the sulpiride treatment it needs to consider the age, the menstrual cycle and the sexual activity.
Lipari Luana, Gerbino Aldo, Farina Elvira, M. Buscemi and Lipari Alessio, 2009. Effects of Sulpiride Treatment on the Hypothalamic Supraoptic and Paraventricular Nuclei. Research Journal of Biological Sciences, 4: 1236-1238.