Authors : Eilyad Issabeagloo, Farhad Ahmadpoor , Parviz Kermanizadeh and Mohammad Taghizadiyeh
Abstract: Methotrexate is one of the acid folic antagonists which are used widely as chemotherapy agent to treatment of kinds of leukemia and other malignancies. It has been suggested that the substance melatonin (5-methoxy-N-acetyltryptamine), discovered by Aaron Lerner in 1958, exists in almost every animal species and possibly even in all plants. In this study, 30 wistar rats were allocated into the 3 groups of 10 rats. Group 1 as control group received normal saline. Group 2 received MTX at the dose of 20 mg kg-1 as ip. Group 3 beside of MTX received melatonin at the dose of 25 mg kg-1 as oral. Results showed that AST and ALT serum levels and hepatic injury in that group received methotrexate were higher than control group and ALT serum level in that group received melatonin plus methotrexate was more than control group and was less than group 2. In this study revealed that melatonin has hepatoprotective effect against methotrexate induced hepatotoxicity in rats.
Eilyad Issabeagloo, Farhad Ahmadpoor , Parviz Kermanizadeh and Mohammad Taghizadiyeh , 2011. Hepatoprotective Actions of Melatonin Against Methotrexate Induced Hepatic Injury in Animal Model. Research Journal of Biological Sciences, 6: 381-385.