Research Journal of Biological Sciences

Year: 2011
Volume: 6
Issue: 12
Page No. 632 - 634

Evaluation of Anti-Fungal Activity of Synthesized Chalcone Semicarbazone Derivatives

Authors : Manmohan Singhal and Arindam Paul

Abstract: In the present study, researchers designed a Pharmacophore Model chalconesemicarbazone which is having hydrogen acceptor site, hydrogen donor site, lipophilic site, etc., using Ligandscout-2.02 software. A series of chalcone semicarbazones was synthesized and evaluated for their anti-fungal activity by Paper Disk Diffusion Method. Based on the results of an anti-fungal study, compound CS-10 was the most active compound. It was observed that methoxy substitution in aldehydic moiety and hydroxyl substitution in the acetophenic moiety significantly increased anti-microbial spectrum against fungi.

How to cite this article:

Manmohan Singhal and Arindam Paul, 2011. Evaluation of Anti-Fungal Activity of Synthesized Chalcone Semicarbazone Derivatives. Research Journal of Biological Sciences, 6: 632-634.

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