Abstract: Permethrin a synthetic pyrethroid poisons are used as insecticide. These toxins can be used insecticides in agriculture and medicine for destruction and/or eradication of ectoparasites of animals. Studies have shown that Permethrin creation seizure effects in different animals. Amlodipine, calcium channel blocker, widely used for treatment of cardiovascular diseases. Studies have shown that the calcium channel blockers are anti-convulsant effects in different animal models. The aim of this study was to determine the effect of Amlodipine on Permethrin-induced seizures in mice. In this experiment, the animals were received different doses of Amlodipine (2.5, 5, 10, 20 and 40 mg kg^-1 b.wt.) intraperitoneally 30 min before intraperitoneal injection of Permethrin (200 mg kg^-1 b.wt). After Permethrin injection, clonic and tonic seizures and finally, death was the fate was investigated. Results showed that Amlodipine dose dependently reduced the severity of Permethrin-induced seizures so that Amlodipine at dose of 10 mg kg^-1 (the lowest, p<0.05) and 40 mg kg^-1 b.wt. (the highest, p<0.001) which had anti-convulsant effects. The anti-convulsant activity of Amlodipine suggests that possibly due to antagonistic effect on voltage-dependent calcium channel.