Authors : Salam Z.Al. Agha, Maged M. Yassin and Naela E. Esleem
Abstract: The present study was aimed to investigate the histopathological and physiological alterations in the liver of male rabbit in response to imidacloprid administration. Rabbits were given orally the dose of 1/10 LD50 imidacloprid daily (mg/100/L) for 8 weeks. Control animals were given distilled water. Upon imidacloprid administration, alanine amino transferase generally showed significant increase throughout the experimental periods with maximum increase in the 2nd and 5th weeks compared to controls (70.8±4.1 v 52.0±3.0 and 65.3±3.9 v 49.8±3.0; % difference = 36.2 and 31.1; p = 0.017 and 0.020, respectively). Aspartate amino transferase was also increased with significant changes at the 3rd, 4th and 5th weeks (49.2±3.0 v 35.7±2.1; 43.2±2.7 v 34.8±1.5 and 43.0±2.1 v 36.1±1.7; % difference = 37.8, 24.1 and 19.1; p = 0.012, 0.031 and 0.047). Alkaline phosphates increased in the first 4 weeks showing maximum increase during the 2nd week compared to controls (129.5±6.3 v 103.3±3.9, % difference = 25.4, p = 0.012). In the last 4 weeks, the enzyme activity decreased with maximum decrease at the 6th week (83.3±.5 v 107.8±5.7, % difference = 22.7, p = 0.018). Similar changed were observed for cholinesterase with maximum increase at the 4th week (6167±235 v 4624±168, % difference = 33.4, p = 0.002) and maximum decrease at the 8th week (3831±233 v 4876±155, % difference = 21.4, p = 0.011.
Salam Z.Al. Agha, Maged M. Yassin and Naela E. Esleem, 2014. Hepatotoxicity of Imidacloprid in Male Rabbit: Physiological and Histological Aspects. Research Journal of Biological Sciences, 9: 24-33.