Abstract: The prevalent changing values and norms have made promiscuous sexual attitude to reach alarming dimension, irrespective of the persistent propaganda on sexually transmitted disease and Acquired Immune Deficiency Syndrome (AIDS) scourge. Consequently, this study attempts to investigate the relationship between Locus of control, self-concept and the reproductive health knowledge of students in tertiary Institutions. The study is essentially a correlational study, which employed the use of questionnaire in sampling the reproductive health knowledge of 1500 students from 6 Nigerian Universities. Three null hypothesis were formulated to guide the investigation. The analysis of data revealed that 2 hypotheses were accepted while one was rejected leading to the findings that: self-concept and locus of control are not correlate of students` reproductive health knowledge. There is a significant relationship in the self-concept of students and their reproductive health knowledge. Students reproductive health knowledge is not significantly related to their locus of control. Given the above findings, the study recommends a provision of adequate reproductive health knowledge through the incorporation of sex education in the school curriculum as well as the re-education of parents and older adults in the society about the new trends and their responsibilities in their children`s sexual development.