Abstract: The urgency of the problem under investigation is conditioned by the fact that the 20th century intensifies the research in the field of culture, related to cultural and historical interaction issues or the dialogue of cultures including the issue of “culture frontier” which is most clearly manifested in the Latin American cultural space. The study aims to identify regional, Latin American specifics of historical and cultural border by addressing the basic conceptual approaches to Latin American humanitarian thought of the second half of the 20th century. The leading approach to the study of this issue is the method of comparative research directed analysis and the comparison of research experience in the Latin American humanitarian thought. The main results in the study reflect the development trends of “culture frontier” in contemporary Latin American scientific thought and the provision of the attempt concerning the historical and cultural specifics of the region development on their basis. The materials of the study may be useful in the cultural study as well as in the studies of historical and philosophical nature.