Abstract: The present research was aimed to compare the personality traits, strategies of coping with stress and locus of control in mothers with deaf and blind children with mothers with normal children. The research method was causal-comparative (after event). The population consisted of all mothers of deaf and blind children and mothers of normal children in Karaj City. Cluster sampling was used in the present research for exceptional and normal schools. Afterwards, all exceptional students including 50 male and 50 female students who had the conditions and specifications of the selected unit of were chosen using purposive sampling method. In addition, 120 students including 60 male and 60 female students were chosen among normal students who were selected using cluster sampling method. Personality type questionnaire of Costa and McCrae, internal-external locus of control questionnaire of Nowicki and Strickland and coping strategies (emotion and problem-oriented) questionnaire of Lazarus and Folkman were employed in order to collect required information. Finally, the collected data was analyzed using statistical methods, standard deviation and variance analysis through SPSS Software. External locus of control in mothers with deaf children was greater than mothers with blind and normal children. There was no difference between mothers with blind and deaf children and mothers with normal children in terms of problem and emotion-oriented coping strategies. Moreover, it can be concluded that neuroticism and extraversion had greater values in mothers with deaf children compared with mothers with deaf and normal children.