Abstract: The effectiveness of interpersonal communication with the development self-concept and self-adjustment raises some research questions. How the interpersonal communication influences the development of self-concept and self-adjustment in individuals who possessed disabilities not in their adolescents specifically is chosen as topic of this research. The subject of the research is individuals who have been registered as members at the foundation of Yayasan Pembina Cacat Tubuh Karya Jasa Utama in Medan city, North Sumatera Province. The research methodology uses a correlation design and ex post facto procedure. Data collection technique uses the questionnaires, the unstructured interview and a participant observation. The result of the research shows that there is a significant relation between interpersonal communication and self-concept and adjustment among the disabilities. It concludes that there is a significant difference of effectiveness of interpersonal communication, self-adjustment and self-concept between the subject of research who have different interpersonal communication effectiveness, self-concept, self-adjustment and people who have disabilities in their adolescents.