Abstract: The purpose of this article is to study trends in the Middle East policy of Turkey in the second half of the twentieth century. In the basis of the work are key components of the policy of Turkey�s relations with the countries of the region. The basic research method is a systematic approach, for the Middle East policy of Turkey is a separate subsystem in the system of foreign policy of Ankara. As tools of historical research were used such methods as historic-genetic and problem-chronological. Historical-genetic method allows us to trace the successive disclosure of changes in the object of this study. Problem-chronological method of study and presentation contributes to the progressive lighting of features of significant events of regional and international importance. As a result of the study a trend of transformation of the Middle East policy of Turkey was revealed. The policy of active rapprochement with the United States and the European Union, adopted by the Turkish leadership, has negatively affected Turkey�s relations with the countries of the Middle East region. Nevertheless, some regional events and the negative results of a one-vector policy, forced Turkey to establish relations with its neighbors, including Syria, relations with which from 1938 were characterized as tensed. In our opinion, the fact that many researchers have noted the priority of relations of Turkey with the West, until the end of the cold war era, quite incorrect, for the analysis of bilateral treaties in the field of trade, culture, security indicates the trend of establishing interstate relations with the countries of the Middle East region (Iraq, Iran, Syria, Israel).