Abstract: The most common cause of failure of the corneal transplant is the rejection by the host immune system for which there areseveral factors. This study was conducted in order to determine the factors influencing on the positivity of the corneal transplant in Imam Khomeini Hospital of Urmia during the years 2013 and 2014. Also, regarding the importance of the corneal transplant surgery, we tried to study the amount of referring for the corneal transplant surgery and investigate it during the years of 2010-2014 and then make predictions through modeling for the coming year. In this cross-sectional study, all patients who during the years 2010-2014 referred to this hospital for corneal transplant surgery were studied. By using the questionnaire, we collected the needed information and analyzed the data by the SPSS Software (the logistic regression) and the models of time series (ARIMA). This study was done on 2014 patients who had been exposed to corneal transplant surgeryby doctor diagnosis. The multivariate inferential statistics of findings showed a significant relation between age and gender of the patient requesting corneal transplant on the one handand selection of the ultimate result of transplant on the other; finally, the age and gender of the patient requesting corneal transplant was entered to model. Also, the time series study was done for 52 months. Finally, the mean of transplant patients referring to this hospital in the next 12 months (2015) has been predicted to be equal to 7/3 case per month. This prediction was estimated by using the model {μ≠0 and ARIMA (1, 1)}. Variables of age and gender of patients requesting corneal transplantsurgery were recognized as the factors affecting the ultimate result of transplant. The results of studying the time series show a reduction in referring to Imam Khomeyni Hospital of Urmia for cataract surgery, although, this reduction is not so considerable.