Research Journal of Pharmacology

Year: 2012
Volume: 6
Issue: 3
Page No. 35 - 47

A Study on Cytotoxicity, Toxicity and Anticancer Activity of Zingiber officinale Roscoe Against Cholangiocarcinoma

Authors : Tullayakorn Plengsuriyakarn, Vithoon Viyanant, Veerachai Eursitthichai, Smarn Tesana, Wanna Chaijaroenkul, Arunporn Itharat and Kesara Na-Bangchang

References

Ambudkar, S.V., C. Kimchi-Sarfaty, Z.E. Sauna and M.M. Gottesman, 2003. P-glycoprotein: From genomics to mechanism. Oncogene, 22: 7468-7485.
CrossRef  |  

Ames, B.N., L.S. Gold and W.C. Willet, 1995. The causes and prevention of cancer. Proc. Natl. Acad. Sci. USA., 92: 5258-5265.
PubMed  |  Direct Link  |  

Bibby, M.C., 2004. Orthotopic models of cancer for preclinical drug evaluation: Advantages and disadvantages. Eur. J. Cancer, 40: 852-857.
PubMed  |  

Bode, A.M., W.Y. Ma, Y.J. Surh and Z. Dong, 2001. Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol. Cancer Res., 61: 850-853.
Direct Link  |  

Boonmars, T., Z. Wu, S. Boonjaruspinyo, S. Pinlaor and I. Nagano et al., 2009. Alterations of gene expression of RB pathway in Opisthorchis viverrini infection-induced cholangiocarcinoma. Parasitol. Res., 105: 1273-1281.
PubMed  |  

Cao, L., M. Duchrow, U. Windhovel, P. Kujath, H.P. Bruch and R. Broll, 1998. Expression of MDR1 mRNA and encoding P-glycoprotein in archival formalin-fixed paraffin-embedded gall bladder cancer tissues. Eur. J. Cancer, 34: 1612-1617.
Direct Link  |  

Chaimuangraj, S., W. Thamavit, H. Tsuda and M.A. Moore, 2003. Experimental investigation of opisthorchiasis-associated cholangiocarcinoma induction in the Syrian hamster-pointers for control of the human disease. Asian Pac. J. Cancer Prev., 4: 87-93.
PubMed  |  

Chauhan, D.P., 2002. Chemotherapeutic potential of curcumin for colorectal cancer. Curr. Pharm. Des., 8: 1695-1706.
PubMed  |  

Chen, C.Y., T.Z. Liu, Y.W. Liu, W.C. Tseng and R.H. Liu et al., 2007. 6-shogaol (alkanone from ginger) induces apoptotic cell death of human hepatoma p53 mutant Mahlavu subline via an oxidative stress-mediated caspase-dependent mechanism. J. Agric. Food Chem., 55: 948-954.
PubMed  |  

Choudhury, D., A. Das, A. Bhattacharya and G. Chakrabarti, 2010. Aqueous extract of ginger shows antiproliferative activity through disruption of microtubule network of cancer cells. Food Chem. Toxicol., 48: 2872-2880.
PubMed  |  

Chrubasik, S., M.H. Pittler and B.D. Roufogalis, 2005. Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles. Phytomedicine, 12: 684-690.
CrossRef  |  PubMed  |  Direct Link  |  

Courtois, A., L. Payen, D. Lagadic, A. Guillouzo and O. Fardel, 1999. Evidence for a multidrug resistance-associated protein 1 (MRP1)-related transport system in cultured rat liver biliary epithelial cells. Life Sci., 64: 763-774.
PubMed  |  

Fava, G., L. Marucci, S. Glaser, H. Francis and S. de Morrow et al., 2005. gamma-aminobutyric acid inhibits cholangiocarcinoma growth by cyclic AMP-dependent regulation of the protein kinase A/extracellular signal-regulated kinase 1/2 pathway. Cancer Res., 65: 11437-11446.
CrossRef  |  

Gigliozzi, A., F. Fraioli, P. Sundaram, J. Lee, A. Mennone, D. Alvaro and J.L. Boyer, 2000. Molecular identification and functional characterization of Mdr1a in rat cholangiocytes. Gastroenterology, 119: 1113-1122.
Direct Link  |  

Gottesman, M.M., T. Fojo and S.E. Bates, 2002. Multidrug resistance in cancer: Role of ATP-dependent transporters. Nature Rev. Cancer, 2: 48-58.
CrossRef  |  Direct Link  |  

Haswell-Elkins, M.R., E. Mairiang, P. Mairiang, J. Chaiyakum and N. Chamadol et al., 1994. Cross-sectional study of Opisthorchis viverrini infection and cholangiocarcinoma in communities within a high-risk area in northeast Thailand. Int. J. Cancer, 59: 505-509.
PubMed  |  

Hejna, M., M. Pruckmayer and M. Raderer, 1998. The role of chemotherapy and radiation in the management of biliary cancer: A review of the literature. Eur. J. Cancer, 34: 977-986.
PubMed  |  

Hoblinger, A., F. Grunhage, T. Sauerbruch and F. Lammert, 2009. Association of the c.3972C>T variant of the multidrug resistance-associated protein 2 Gene (MRP2/ABCC2) with susceptibility to bile duct cancer. Digestion, 80: 36-39.

Hsu, Y.L., P.L. Kuo, T.F. Tzeng, S.C. Sung, M.H. Yen, L.T. Lin and C.C. Lin, 2008. Huang-lian-jie-du-tang, a traditional Chinese medicine prescription, induces cell-cycle arrest and apoptosis in human liver cancer cells in vitro and in vivo. J. Gastroenterol. Hepatol., 23: 290-299.
PubMed  |  

Huang, M.T., T. Lysz, T. Ferraro, T.F. Abidi, J.D. Laskin and A.H. Conney, 1991. Inhibitory effects of curcumin on in Vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res., 51: 813-819.
Direct Link  |  

Iki, K., T. Tsujiuchi, T. Majima, H. Sakitani and M. Tsutsumi et al., 1998. Increased telomerase activity in intrahepatic cholangiocellular carcinomas induced by N-nitrosobis(2-oxopropyl)amine in hamsters. Cancer Lett., 131: 185-190.
PubMed  |  

Imray, C.H., K.M. Newbold, A. Davis, M. Lavelle-Jones and J.P. Neoptolemos, 1992. Induction of cholangiocarcinoma in the golden Syrian hamster using methylazoxymethyl acetate. Eur. J. Surg. Oncol., 18: 373-378.
PubMed  |  

Jan, Y.Y., T.S. Yeh, J.N. Yeh, H.R. Yang and M.F. Chen, 2004. Expression of epidermal growth factor receptor, apomucins, matrix metalloproteinases and p53 in rat and human cholangiocarcinoma: Appraisal of an animal model of cholangiocarcinoma. Ann. Surg., 240: 89-94.
Direct Link  |  

Jimeno, A., B. Rubio-Viqueira, M.L. Amador, D. Oppenheimer and N. Bouraoud et al., 2005. Epidermal growth factor receptor dynamics influences response to epidermal growth factor receptor targeted agents. Cancer Res., 65: 3003-3010.
PubMed  |  

Johnson, J.I., S. Decker, D. Zaharevitz, L.V. Rubinstein and J.M. Venditti et al., 2001. Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials. Br. J. Cancer, 84: 1424-1431.
PubMed  |  

Kim, E.C., J.K. Min, T.Y. Kim, S.J. Lee and H.O. Yang et al., 2005. [6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo. Biochem. Biophys. Res. Commun., 335: 300-308.
CrossRef  |  PubMed  |  Direct Link  |  

Kim, S.O., J.K. Kundu, Y.K. Shin, J.H. Park, M.H. Cho, T.Y. Kim and Y.J. Surh, 2005. [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin. Oncogene., 41: 2558-2567.
PubMed  |  

Kiuchi, F., M. Shibuya and U. Sankawa, 1982. Inhibitors of prostaglandin biosynthesis from ginger. Chem. Pharm. Bull., 30: 754-757.
PubMed  |  

Kiuchi, F., S. Iwakami, M. Shibuya, F. Hanaoka and U. Sankawa, 1992. Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids. Chem. Pharmaceut. Bull., 40: 387-391.
CrossRef  |  PubMed  |  Direct Link  |  

Lai, G.H., Z. Zhang, X.N. Shen, D.J. Ward and J.L. Dewitt et al., 2005. erbB-2/neu transformed rat cholangiocytes recapitulate key cellular and molecular features of human bile duct cancer. Gastroenterology, 129: 2047-2057.
PubMed  |  

Larkin, A., L. O'Driscoll, S. Kennedy, R. Purcell and E. Moran et al., 2004. Investigation of MRP-1 protein and MDR-1 P-glycoprotein expression in invasive breast cancer: A prognostic study. Int. J. Cancer, 112: 286-294.
PubMed  |  

Lee, C.H., 2004. Reversing agents for ATP-binding cassette (ABC) transporters: Application in modulating multidrug resistance (MDR). Curr. Med. Chem. Anticancer Agents, 4: 43-52.
PubMed  |  

Lee, E., K.K. Park, J.M. Lee, K.S. Chun, J.Y. Kang, S.S. Lee and Y.J. Surh, 1998. Suppression of mouse skin tumor promotion and induction of apoptosis in HL-60 cells by Alpinia oxyphylla Miquel (Zingiberaceae). Carcinogenesis (Lond.), 19: 1377-1381.

Lee, H.S., E.Y. Seo, N.E. Kang and W.K. Kim, 2008. [6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells. J. Nutr. Biochem., 19: 313-319.
Direct Link  |  

Ling, H., H. Yang, S.H. Tan, W.K. Chui and E.H. Chew, 2010. 6-shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation. Br. J. Pharmacol., 161: 1763-1777.
CrossRef  |  Direct Link  |  

Liu, Z.H., Y.P. He, Y. Zhou, P. Zhang and H. Qin, 2011. Establishment and identification of the human multi-drug-resistant cholangiocarcinoma cell line QBC939/ADM. Mol. Biol. Rep., 38: 3075-3082.
CrossRef  |  PubMed  |  

Lonning, P.E., 2003. Study of suboptimum treatment response: Lessons from breast cancer. Lancet Oncol., 4: 177-185.

Marienfeld, C., L. Tadlock, Y. Yamagiwa and T. Patel, 2003. Inhibition of cholangiocarcinoma growth by tannic acid. Hepatology, 37: 1097-1104.
PubMed  |  

Maronpot, R.R., H.D. Giles, D.J. Dykes and R.D. Irwin, 1991. Furan-induced hepatic cholangiocarcinomas in Fischer 344 rats. Toxicol. Pathol., 19: 561-570.
PubMed  |  

Mosconi, S., G.D. Beretta, R. Labianca, M.G. Zampino, G. Gatta and V. Heinemann, 2009. Cholangiocarcinoma. Crit. Rev. Oncol. Hematol., 69: 259-270.

Moungjaroen, J., U. Nimmannit, P.S. Callery, L. Wang and N. Azad et al., 2006. Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation. J. Pharmacol. Exp. Ther., 319: 1062-1069.
CrossRef  |  

Naus, P.J., R. Henson, G. Bleeker, H. Wehbe, F. Meng and T. Patel, 2007. Tannic acid synergizes the cytotoxicity of chemotherapeutic drugs in human cholangiocarcinoma by modulating drug efflux pathways. J. Hepatol., 46: 222-229.
PubMed  |  

Nita, M.E., O. Tominaga, H. Nagawa, T. Tsuruo and T. Muto, 1998. Dihydropyrimidine dehydrogenase but not thymidylate synthase expression is associated with resistance to 5-fluorouracil in colorectal cancer. Hepatogastroenterology, 45: 2117-2122.
PubMed  |  

Park, K.K., K.S. Chun, J.M. Lee, S.S. Lee and Y.J. Surh, 1998. Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice. Cancer Lett., 129: 139-144.
CrossRef  |  PubMed  |  Direct Link  |  

Pereira, M.M., R. Haniadka, P.P. Chacko, P.L. Palatty and M.S. Baliga, 2011. Zingiber officinale roscoe (ginger) as an adjuvant in cancer treatment: A review. J. BUON., 16: 414-424.
PubMed  |  

Pinlaor, S., Y. Hiraku, N. Ma, P. Yongvanit and R. Semba et al., 2004. Mechanism of NO-mediated oxidative and nitrative DNA damage in hamsters infected with Opisthorchis viverrini: A model of inflammation-mediated carcinogenesis. Nitric Oxide, 11: 175-183.
PubMed  |  

Rost, D., J. Konig, G. Weiss, E. Klar, W. Stremmel and D. Keppler, 2001. Expression and localization of the multidrug resistance proteins MRP2 and MRP3 in human gallbladder epithelia. Gastroenterology, 121: 1203-1208.
PubMed  |  

Sausville, E.A. and A.M. Burger, 2006. Contributions of human tumor xenografts to anticancer drug development. Cancer. Res., 66: 3351-3354.
CrossRef  |  

Schoonen, W.G.E.J., J.A.D.M. de Roos, W.M.A. Westerink and E. Debiton, 2005. Cytotoxic effects of 110 reference compounds on HepG2 cells and for 60 compounds on HeLa, ECC-1 and CHO cells.: II mechanistic assays on NAD(P)H, ATP and DNA contents. Toxicol. In vitro, 19: 491-503.
CrossRef  |  PubMed  |  Direct Link  |  

Shukla, Y. and M. Singh, 2007. Cancer preventive properties of ginger: A brief review. Food Chem. Toxicol., 45: 683-690.
CrossRef  |  PubMed  |  Direct Link  |  

Sirica, A.E., Z. Zhang, G.H. Lai, T. Asano and X.N. Shen et al., 2008. A novel "patient-like" model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines. Hepatology, 47: 1178-1190.
CrossRef  |  

Sriamporn, S., P. Pisani, V. Pipitgool, K. Suwanrungruang, S. Kamsa-ard and D.M. Parkin, 2004. Prevalence of Opisthorchis viverrini infection and incidence of cholangiocarcinoma in Khon Kaen, Northeast Thailand. Trop. Med. Int. Health, 9: 588-594.
PubMed  |  

Surh, Y.J., 2003. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer, 3: 768-780.
CrossRef  |  PubMed  |  Direct Link  |  

Surh, Y.J., J.Y. Lee, K.J. Choi and S.R. Ko, 2002. Effects of selected ginsenosides on phorbol ester-induced expression of cyclooxygenase-2 and activation of NF-kappaB and ERK1/2 in mouse skin. Ann. N. Y. Acad. Sci., 973: 396-401.
PubMed  |  

Surh, Y.J., K.K. Park, K.S. Chun, L.J. Lee, E. Lee and S.S. Lee, 1999. Anti-tumor-promoting activities of selected pungent phenolic substances present in ginger. J. Environ. Pathol. Toxicol. Oncol., 18: 131-139.
PubMed  |  Direct Link  |  

Suzuki, F., M. Kobayashi, Y. Komatsu, A. Kato and R.B. Pollard, 1997. Keishi-ka-kei-to, a traditional Chinese herbal medicine, inhibits pulmonary metastasis of B16 melanoma. Anticancer Res., 17: 873-878.
PubMed  |  Direct Link  |  

Szabo, M.R., C. Iditoiu, D. Chambre and A.X. Lupea, 2007. Improved DPPH determination for antioxidant activity spectrophotometric assay. Chem. Papers, 61: 214-216.
CrossRef  |  

Tengchaisri, T., R. Chawengkirttikul, N. Rachaphaew, V. Reutrakul, R. Sangsuwan and S. Sirisinha, 1998. Antitumor activity of triptolide against cholangiocarcinoma growth in vitro and in hamsters. Cancer Lett., 133: 169-175.
PubMed  |  

Tepsiri, N., L. Chaturat, B. Sripa, W. Namwat, S. Wongkham, V. Bhudhisawasdi and W. Tassaneeyakul, 2005. Drug sensitivity and drug resistance profiles of human intrahepatic cholangiocarcinoma cell lines. World J. Gastroenterol., 11: 2748-2753.
PubMed  |  

Tesana, S., Y. Takahashi, P. Sithithaworn, K. Ando and T. Sakakura et al., 2000. Ultrastructural and immunohistochemical analysis of cholangiocarcinoma in immunized Syrian golden hamsters infected with Opisthorchis viverrini and administered with dimethylnitrosamine. Parasitol. Int., 49: 239-251.
PubMed  |  

Tew, K.D., 1994. Glutathione-associated enzymes in anticancer drug resistance. Cancer Res., 54: 4313-4320.
PubMed  |  

Thamavit, W., C. Pairojkul, D. Tiwawech, M. Itoh, T. Shirai and N. Ito, 1993. Promotion of cholangiocarcinogenesis in the hamster liver by bile duct ligation after dimethylnitrosamine initiation. Carcinogenesis, 14: 2415-2417.
CrossRef  |  

Thamavit, W., N. Bhamarapravati, S. Sahaphong, S. Vajrasthira and S. Angsubhakorn, 1978. Effects of dimethylnitrosamine on induction of cholangiocarcinoma in Opisthorchis viverrini-infected Syrian golden hamsters. Cancer Res., 38: 4634-4639.
PubMed  |  

Vapiwala, N., R. Mick, M.K. Hampshire, J.M. Metz and A.S. DeNittis, 2006. Patient initiation of complementary and alternative medical therapies (CAM) following cancer diagnosis. Cancer J., 12: 467-474.
PubMed  |  

Voskoglou-Nomikos, T., J.L. Pater and L. Seymour, 2003. Clinical predictive value of the in vitro cell line, human xenograft and mouse allograft preclinical cancer models. Clin. Cancer Res., 9: 4227-4239.
Direct Link  |  

Wang, H., M.G. Nair, G.M. Strasburg, Y.C. Chang, A.M. Booren, J.I. Gray and D.L. DeWitt, 1999. Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries. J. Nat. Prod., 62: 294-296.
CrossRef  |  PubMed  |  Direct Link  |  

Weng, C.J., C.F. Wu, H.W. Huang, C.T. Ho and G.C. Yen, 2010. Anti-invasion effects of 6-shogaol and 6-gingerol, two active components in ginger, on human hepatocarcinoma cells. Mol. Nutr. Food Res., 54: 1618-1627.
PubMed  |  

Xu, X., S. Kobayashi, W. Qiao, C. Li and C. Xiao et al., 2006. Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J. Clin. Invest., 116: 1843-1852.
CrossRef  |  

Young, L.C., B.G. Campling, T. Voskoglou-Nomikos, S.P. Cole, R.G. Deeley and J.H. Gerlach, 1999. Expression of multidrug resistance protein-related genes in lung cancer: Correlation with drug response. Clin. Cancer. Res., 5: 673-680.
PubMed  |  

Design and power by Medwell Web Development Team. © Medwell Publishing 2024 All Rights Reserved