Abstract: Foot-and-Mouth Disease (FMD) is the most contagious, acute and economically important transboundary animal disease affecting cloven hoofed wild and domestic animals. It is caused by a virus that belongs to the genus aphthovirus of the family picornaviridae. There are seven recognized serotypes of FMD (O, A, C, Asia1, SAT1, SAT2 and SAT3) which differ in distribution across the world. It becomes endemic in Ethiopia and leads a great economic loss in the livestock’s sector. Therefore, the objective of this study is to review the epidemiology and economic impact of FMD in Ethiopia. The seroprevalence, temporal, serotype and regional distribution, topotypes present, the direct and indirect economic impacts of FMD in Ethiopia are reviewed in this seminar paper. Foot and mouth disease outbreaks are occurred in Ethiopia every year and reported from all regions of the country. However, most of the outbreaks are reported from central, Southern and Southeastern part of Ethiopia associated with the movement of animals for trade, agro ecology, animal density and production system of the community. These outbreaks of FMD results in huge economic loss directly due to production losses and indirectly due to export restriction, control and prevention costs. Therefore, the epidemiology of the serotypes present should be studied in detail. This helps to develop a vaccine which is effective to all the serotypes present in Ethiopia. Control of animal’s movement should be strengthened to limit spreading of serotypes.