Authors : Lawrence M. Agius
Abstract: Many attributes of a neoplastic proliferative and spreading phenomenon appear to directly arise as perivascular processes and as transforming and amplified response of infiltrated stroma. Growth factor participation would operatively interact with neovascularization in subsequently inducing progression of a neoplasm that spreads both locally and systemically. Such patterns of transformation would self-amplify in the subsequent evolution of a tumor that is characterized by paracrine and autocrine effect. It is in terms of such lesions inherently infiltrating stroma that metastatic spread implicates clonal groups of tumor cells in participation with neovascularization and endothelial proliferation and migration.
Lawrence M. Agius , 2005. Perivascular Attributes of Transformation and of Amplification in Tumor Cell Infiltration. International Journal of Molecular Medicine and Advance Sciences, 1: 369-374.