Abstract: Epigenesis in malignant evolution would transform mechanics of development of genetic mutation in terms of failure of DNA repair pathways. Genetic instability would be an expressed result of the development of mutagenesis that includes such failed DNA repair mechanisms. The cytokine/chemokine axis of influence in terms of carcinogenesis might particularly implicate proliferation of cells and infiltration of stroma involving also targeted action of trophic factors. Epigenesis would be an expression of a malignant transformation event that incorporates various modes of evolution in DNA mutagenesis. DNA mutations that develop as multiple pathways of impaired subsequent mutational repair mechanisms would both account for and extend the influence of genetic instability systems in carcinogenesis. One might recognize a full array of mechanistic events inherent to a concept of transformational processes both originating and subsequently promoting various systems of tropism and trophism even as the cellular clonality is itself extended beyond the initial carcinogenetic focus.