Abstract: Our project entitled: ` The statistical analysis to extract the activity beyond technic BOLD of IRMf`. The goal of this theme is to study and to explore the technique of BOLD (Blood Oxygenation Level Dependent) of IRMf type, this technique is the most used for the detection`s variations of oxygenation and blood fluxes bound to the activity neuronal in vivo. The functional magnetic imaging IRM (IRMf) is used by the Neurologists, Physicists and Mathematicians who work on the brain activation card. For the treatment of the IRMf data several methods, algorithms mathematical have been elaborated for the calculation`s regions of cerebral activations that demand complex software tools and powerful computer platforms, either in the medical clinics or in the centers of research on the IRMf due to the complexity and to the volume of the data treated. Among these tools in the research domain we can found The SPM Toolbox (Matlab environment), a tool of research pioneer in the analysis of both PET and IRMf data. After the pre-treatment of data bus where we use the spm, we applied an analyse statistic with student t-test to explore the activity and inject it on the talairach glass.