Authors : H.E. Mohamed, A. Alhaidary and A.C. Beynen
Abstract: High magnesium intakes are known to inhibit the development of nephrocalcinosis in female rats but there was no information on the dose-response relationship and the underlying mechanism. In an attempt to collect the lacking information, female rats were fed diets containing 0.02-0.24% magnesium as the only variable. Increasing dietary magnesium concentrations were found to reduce nephrocalcinosis in a dose-dependent fashion. The lowest dietary magnesium level produced a kidney calcium concentration of 10.6% in the dry matter whereas the highest magnesium intake reduced kidney calcium to 0.2%. Increasing dietary magnesium concentrations produced increasing urinary magnesium concentrations in combination with decreasing phosphorus concentrations. It is suggested that the magnesium-induced inhibition of nephrocalcinosis is caused by a decrease in urinary phosphorus and increase in urinary magnesium.
H.E. Mohamed, A. Alhaidary and A.C. Beynen, 2010. Nephrocalcinosis and Urinary Mineral Concentrations in Rats Fed Diets Containing Various Concentrations of Magnesium. Journal of Animal and Veterinary Advances, 9: 2405-2408.