Abstract: This study investigated the effect of cryotherapy combined with warm transfusion on vital signs, inflammatory response and tissues permeability in rabbits with severe burns. Rabbits were subjected to deep partial-thickness scald covering of 40% Total Body Surface Area (TBSA). Rabbits were randomly divided into 4 groups namely scald group (A), cryotherapy after scald group (B), warm transfusion after scald group (C), group of cryotherapy combined with warm transfusion after scald (D). Cryotherapy meant soaking the burn wound in 10°C cold water for 40 min after scald 5 min. Fluid of warm transfusion was maintained at 39. This data shown that cryotherapy decreased the core body temperature, Mean Arterial Pressure (MAP) and wound Myeloperoxidase (MPO) activity in rabbits and increased the levels of reduced shear viscosity/erythrocyte aggregation and inflammatory mediators compared to control group. The upper indicators produced the opposite changes under warm transfusion. Moisture content of lung in group C and moisture content of wound in group B were lower compared to group A. Moreover, burn wound MPO, moisture content of lung and wound and inflammatory mediators significantly descended in group D.
Chunliu Lv, Pihong Zhang, Xiaoyuan Huang, Jizhang Zeng, Licheng Ren and Pengfei Liang, 2012. Cryotherapy Combined with Warm Transfusion Apply to Serious Burns in a Rabbit Model: An Experimental Study. Journal of Animal and Veterinary Advances, 11: 2641-2646.