Abstract: This study present a new method for optimizing the power conversion efficiency of the Biological Photovoltaic cells (BPVs). In this method, the electronic circuits that operate within ultra low power range is used rather than propose new strategies for facilitating the electrons transfer to the anode inside the cell through design new electrodes coupled with the use of different species of photoautotrophic organisms. The proposed method includes building a Nano-Powered Transconductance Amplifier (NPTA) using the Electrically Programmable Analog Devices (EPAD). The NPTA is designed with a special topology, through which the output voltage is almost equal to the open-circuit voltage of the BPV cell and the output current is boosted by the large trans conductance of the NPTA. The new approach exhibits a large increase in the power conversion of the BPVs which can be utilized to power the electronic devices.