Abstract: Smart healthcare and biomedical informatics application system will be a major big data platform for the healthcare and medical information systems in the human wellness life service. With the wellness big data resources in the healthcare service with human life-care hospital network environment, smart digital biomedical system will be growing and taking the next generation model for the human information management system beyond electronics and software solution in the next generation healthcare. Three parts in the data collection situation are medical disease data, personal genomic data and life log data from the smart wearable devices with some vital data. Various types of disease data will be taken from medical information system in hospital to cope with healthcare resources and patient’s symptom involving different platform related services. Biomedical informatics platform and smart agent as Clinical Decision Support System (CDSS) will be extended to produce some activation to this service. Smart health avatar assisted and cooperated with these data resource to deal with personalizing precision and preventive forecast solution for the future healthcare service environment. Some cases of this coming situation in the ubiquitous life care prevention, the u-Healthcare, u-Silver and smart health avatar in the biomedical informatics systems can be shown as some configuration and analyzed feature with verified systems during these days.