Authors : Siti Norhajah Hashim, Nasir Mohamad, Zulkifli Mustapha, Nor Hidayah Abu Bakar, Khairi Che Mat, Syed Hadzrullathfi Syed Omar and Mohd Shahril Bin Othman
Abstract: Withdrawal from chronic opiates is associated with an increase in anxiety behaviours but the anxiety activity in the morphine-dependent and tolerance animals is not clear. Therefore, aim of this study was to examine the effect of honey on the anxiety activity in both morphine-dependent animals. Rats were injected with bi-daily doses (10 mg/kg, at 12 h intervals) of morphine over a period of 7 days. Honey (200 mg/kg, i.g.) was given 15 min. before morphine. Following these injections, anxiety behaviours were tested in the open field test. We found the open test, the morphine-dependent and tolerance in group Morp+Sal made significantly reduce anxiety activity compare with control group. Centre square duration, stretch attend postures and grooming shown a significant value in Morphine+Honey (Morp+H), Morphine+Methadone (Morp+Met), Morphine+Methadone+Honey (Morp+Met+H) compare with Morphine+Saline (Morp+Sal), p<0.05. However, there was no significant difference in another score of measurement in morphine-dependent rats as compared to the control groups. We conclude that honey decreases the severity of the anxiety behaviours in both morphine-dependent and tolerance rats. Thus, honey could be a potential natural method to decrease some of the deleterious behavioural consequences of opiate abuse.
Siti Norhajah Hashim, Nasir Mohamad, Zulkifli Mustapha, Nor Hidayah Abu Bakar, Khairi Che Mat, Syed Hadzrullathfi Syed Omar and Mohd Shahril Bin Othman, 2019. Honey Reduces Anxiety in Morphine-Dependent Rats: An Exploratory and Locomotor Model. Journal of Engineering and Applied Sciences, 14: 9315-9320.