Authors : Afsaneh Norouzi , Houshang Talebi , Shaban-ali Alizadeh , Shahin Fateh , Ali Mohamadzadeh , Payam Eghtesadi-Araghi and Fatemeh Djamshidi
Abstract: Buprenorphine is classified as an agonist-antagonist mu opioid agonist, which has a longer half-life compared with other opioids. The objective of this study was, to evaluate the efficacy of pre-anesthetic administration of buprenorphine on postoperative pain intensity, in patients undergoing hemorrhoidectomy. In a prospective, double-blinded, randomized study, 60 ASA I and II subjects with age of 15-65 years scheduled for elective hemorrhoidectomy under general anesthesia were enrolled. They were randomly allocated to receive sublingual buprenorphine (0.4 mg, 30 min before surgery) or placebo. All the patients were anaesthetized with halothane N2O/O2 after induction with thiopentone. Pain scores, as assessed by a visual analog scale, were evaluated immediately, 2, 4 and 6 h postoperatively. Total dose of analgesics and time of the first request for an analgesic medication were measured as well.The pain scores in buprenorphine group were similar to that in control group immediately and 2 h postoperatively. The postoperative pain intensities in 4 and 6 h following surgery were significantly lower in patients receiving buprenorphine compared with control group (3.83±2.50 vs. 5.27±2.63 and 1.60±2.63 vs. 4.40±2.59, respectively). Patients in buprenorphine group have a significantly longer time to first analgesic request (3.59±0.82 vs. 1.90±0.64 h); however, groups were comparable regarding total dose of analgesic consumption.
Afsaneh Norouzi , Houshang Talebi , Shaban-ali Alizadeh , Shahin Fateh , Ali Mohamadzadeh , Payam Eghtesadi-Araghi and Fatemeh Djamshidi , 2009. Pre-Anesthetic Administration of Sublingual Buprenorphine forPostoperative Analgesia after Hemorrhoidectomy a Clinical Trial. Research Journal of Biological Sciences, 4: 227-230.