Authors : Mehrdad Modaresi and Shekoofe Khosravian
Abstract: The Garden Angelica (Angelica archangelica) in the past time was used as an hematopoiesis plant. With this point that the importance of hematopoiesis and use of herbal medicines instead of chemical medicines that have side effects, this research has studying the effect of Angelica archangelica hydroalcohol extract on the blood parameters in mice. About 40 mature mices were divided into 5 groups. The control group did not receive any extract, the placebo group received 0.5 cc normal saline every other day and 3 treatment groups received extract with (50, 100, 200) mg/kg/2 days doses that was used IP injection. Then the blood samples were taken from the mices. Study blood parameters show that the extract markedly increased the total number of white blood cells in groups 1-3. The number of red blood cells increased significantly in group 3 compared with the control group but 1 and 2 groups have not increased significantly compared to control group. This extract was caused change in the hematocrit, hemoglobin and as for the index of red blood cells (MCV, MCH and MCHC) that have not statistical significant. The extract of Angelica archangelica can effective in hematopoiesis with increase the number of red blood cells and support the immune system with increase the number of white blood cells.
Mehrdad Modaresi and Shekoofe Khosravian, 2011. Effect of Angelica archangelica Extract on Histopathologic Changes in Mice Blood. Research Journal of Biological Sciences, 6: 167-169.